By: Ana Reisdorf, MS, RD
In any health assessment, after gathering general information, I always start by asking questions about gut health. I do this because even if you don’t have any digestive issues, health begins in the gut. But true health encompasses the whole body, so once the gut is handled, we have to tackle all other areas.
Probiotics are frequently recommended for gut health, but their benefits can go away beyond digestion. FEM-PRO 59.5 by Doctor’s Pick is a probiotic designed specifically for women’s total health to address the most common concerns women face, such as hormonal balance, skin health, weight management, and energy. It is also the only probiotic supplement on the market with saffron, which can help with mood, stress and anxiety.
FEM-PRO 59.9: More than Digestive Health
Your microbiome is not just limited to the gut. There are millions of bacterial species living on every part of your body, playing a role in every aspect of your health. FEM-PRO 59.5 contains a variety of probiotics to tackle every area of a woman’s health. It contains 17 different strains in optimal ratios to support mental, hormonal, immune, heart, and vaginal health.
Ingredients in FEM-PRO 59.5 & BENEFITS:
PREBIOTICS IN FEM PRO:
FEM-PRO 59.5 also contains saffron, an aromatic spice that has been evaluated in multiple clinical studies to improve mood, manage symptoms of PMS, and help optimize brain function.
Not all probiotics are created equal
Have you ever taken a probiotic for several months, only to experience unpleasant side effects or no effects at all? That is because many probiotic formulas are loaded with cheaper probiotic strains (usually L acidophilus), and use only trace amounts of the more effective (and more expensive) strains. This is why so many probiotic formulas say their formula is “proprietary”—they hide the fact they’re mostly using the cheapest strains by not showing the amount of each probiotic strain that is actually in the formula.
In contrast, FEM-PRO 59.5, shows the exact amounts of each probiotic strain. You should know what you are putting in your body.
Another issue is that many probiotics contain artificial sweeteners or other fillers. These ingredients either have no effect on your health or as in the case of sweeteners, can negatively impact your body’s natural microbiome. FEM-PRO 59.5, on the other hand, contains no artificial sweeteners or fillers of any kind.
FEM-PRO 59.5 was carefully designed to optimize women’s health. Its carefully selected 17 strains hep address the most common concerns women have from mood to immunity to skin health. You deserve the best for your health. FEM-PRO 59.5 can help you reach your goals.
- Hong Y-F, Kim H, Kim HS, Park WJ, Kim J-Y, Chung DK. Lactobacillus acidophilus K301 Inhibits Atherogenesis via Induction of 24 (S), 25-Epoxycholesterol-Mediated ABCA1 and ABCG1 Production and Cholesterol Efflux in Macrophages. PLoS One. 2016;11(4):e0154302.
- Mastromarino P, Macchia S, Meggiorini L, et al. Effectiveness of Lactobacillus-containing vaginal tablets in the treatment of symptomatic bacterial vaginosis. Clin Microbiol Infect. 2009;15(1):67-74.
- Chen L, Liu W, Li Y, et al. Lactobacillus acidophilus ATCC 4356 attenuates the atherosclerotic progression through modulation of oxidative stress and inflammatory process. Int Immunopharmacol. 2013;17(1):108-115.
- Yu Q, Zhu L, Wang Z, Li P, Yang Q. Lactobacillus delbrueckii ssp. lactis R4 prevents Salmonella typhimurium SL1344-induced damage to tight junctions and adherens junctions. J Microbiol. 2012;50(4):613-617.
- Moro-García MA, Alonso-Arias R, Baltadjieva M, et al. Oral supplementation with Lactobacillus delbrueckii subsp. bulgaricus 8481 enhances systemic immunity in elderly subjects. Age . 2013;35(4):1311-1326.
- Kato-Kataoka A, Nishida K, Takada M, et al. Fermented milk containing Lactobacillus casei strain Shirota prevents the onset of physical symptoms in medical students under academic examination stress. Benef Microbes. 2016;7(2):153-156.
- Alipour B, Homayouni-Rad A, Vaghef-Mehrabany E, et al. Effects of Lactobacillus casei supplementation on disease activity and inflammatory cytokines in rheumatoid arthritis patients: a randomized double-blind clinical trial. Int J Rheum Dis. 2014;17(5):519-527.
- Hwang JW, Baek Y-M, Yang KE, et al. Lactobacillus casei extract induces apoptosis in gastric cancer by inhibiting NF-κB and mTOR-mediated signaling. Integr Cancer Ther. 2013;12(2):165-173.
- Hill D, Sugrue I, Tobin C, Hill C, Stanton C, Ross RP. The Lactobacillus casei Group: History and Health Related Applications. Front Microbiol. 2018;9:2107.
- Cox AJ, Pyne DB, Saunders PU, Fricker PA. Oral administration of the probiotic Lactobacillus fermentum VRI-003 and mucosal immunity in endurance athletes. Br J Sports Med. 2010;44(4):222-226.
- Pan DD, Zeng XQ, Yan YT. Characterisation of Lactobacillus fermentum SM-7 isolated from koumiss, a potential probiotic bacterium with cholesterol-lowering effects. J Sci Food Agric. 2011;91(3):512-518.
- Mikelsaar M, Zilmer M. Lactobacillus fermentum ME-3 – an antimicrobial and antioxidative probiotic. Microb Ecol Health Dis. 2009;21(1):1-27.
- Kadooka Y et al. Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomized controlled trial. Br J Nutr. 2013 Nov 14;110(9):1696-703.Epub 2013 Apr 25
- Miyoshi M et al. Anti-obesity effect of Lactobacillus gasseri SBT2055 accompanied by inhibition of pro-inflammatory gene expression in the visceral adipose tissue in diet-induced obese mice.Eur J Nutr. 2014;53(2):599-606. doi: 10.1007/s00394-013-0568-9. Epub 2013 Aug 6.
- Miyazawa K, Kawase M, Kubota A, et al. Heat-killed Lactobacillus gasseri can enhance immunity in the elderly in a double-blind, placebo-controlled clinical study. Benef Microbes. 2015;6(4):441-449.
- Liang S, Wang T, Hu X, et al. Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress. Neuroscience. 2015;310:561-577.
- Messaoudi M, Lalonde R, Violle N, et al. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr. 2011;105(5):755-764.
- Nishimura M, Ohkawara T, Tetsuka K, et al. Effects of yogurt containing Lactobacillus plantarum HOKKAIDO on immune function and stress markers. Afr J Tradit Complement Altern Med. 2016;6(3):275-280.
- Ferreira Dos Santos T, Alves Melo T, Almeida ME, Passos Rezende R, Romano CC. Immunomodulatory Effects of Lactobacillus plantarum Lp62 on Intestinal Epithelial and Mononuclear Cells. Biomed Res Int. 2016;2016:8404156.
- Chew SY, Cheah YK, Seow HF, Sandai D, Than LTL. Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 exhibit strong antifungal effects against vulvovaginal candidiasis-causing Candida glabrata isolates. J Appl Microbiol. 2015;118(5):1180-1190.
- Mu Q, Tavella VJ, Luo XM. Role of Lactobacillus reuteri in Human Health and Diseases. Front Microbiol. 2018;9:757.
- Recine N, Palma E, Domenici L, et al. Restoring vaginal microbiota: biological control of bacterial vaginosis. A prospective case-control study using Lactobacillus rhamnosus BMX 54 as adjuvant treatment against bacterial vaginosis. Arch Gynecol Obstet. 2016;293(1):101-107.
- Szajewska H, Kołodziej M. Systematic review with meta-analysis: Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea in children and adults. Aliment Pharmacol Ther. 2015;42(10):1149-1157.
- Fabbrocini G, Bertona M, Picazo Ó, Pareja-Galeano H, Monfrecola G, Emanuele E. Supplementation with Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne. Benef Microbes. 2016;7(5):625-630.
- Sanchez M, Darimont C, Drapeau V, et al. Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women. Br J Nutr. 2014;111(8):1507-1519.
- Segers ME, Lebeer S. Towards a better understanding of Lactobacillus rhamnosus GG–host interactions. Microb Cell Fact. 2014;13 Suppl 1:S7.
- Pugh JN, Sparks AS, Doran DA, et al. Four weeks of probiotic supplementation reduces GI symptoms during a marathon race. Eur J Appl Physiol. 2019;119(7):1491-1501.
- Langkamp-Henken B, Rowe CC, Ford AL, et al. Bifidobacterium bifidum R0071 results in a greater proportion of healthy days and a lower percentage of academically stressed students reporting a day of cold/flu: a randomised, double-blind, placebo-controlled study. Br J Nutr. 2015;113(3):426-434.
- Tajabadi-Ebrahimi M, Sharifi N, Farrokhian A, et al. A Randomized Controlled Clinical Trial Investigating the Effect of Synbiotic Administration on Markers of Insulin Metabolism and Lipid Profiles in Overweight Type 2 Diabetic Patients with Coronary Heart Disease. Exp Clin Endocrinol Diabetes. 2017;125(1):21-27.
- Kano M, Masuoka N, Kaga C, et al. Consecutive Intake of Fermented Milk Containing Bifidobacterium breve Strain Yakult and Galacto-oligosaccharides Benefits Skin Condition in Healthy Adult Women. Biosci Microbiota Food Health. 2013;32(1):33-39.
- Mori N, Kano M, Masuoka N, et al. Effect of probiotic and prebiotic fermented milk on skin and intestinal conditions in healthy young female students. Biosci Microbiota Food Health. 2016;35(3):105-112.
- Taghizadeh M, Hashemi T, Shakeri H, et al. Synbiotic food consumption reduces levels of triacylglycerols and VLDL, but not cholesterol, LDL, or HDL in plasma from pregnant women. Lipids. 2014;49(2):155-161.
- Tajadadi-Ebrahimi M, Bahmani F, Shakeri H, et al. Effects of daily consumption of synbiotic bread on insulin metabolism and serum high-sensitivity C-reactive protein among diabetic patients: a double-blind, randomized, controlled clinical trial. Ann Nutr Metab. 2014;65(1):34-41.
- Rogha M, Esfahani MZ, Zargarzadeh AH. The efficacy of a synbiotic containing Bacillus Coagulans in treatment of irritable bowel syndrome: a randomized placebo-controlled trial. Gastroenterol Hepatol Bed Bench. 2014;7(3):156-163.
- Ratna Sudha M, Yelikar KA, Deshpande S. Clinical Study of Bacillus coagulans Unique IS-2 (ATCC PTA-11748) in the Treatment of Patients with Bacterial Vaginosis. Indian J Microbiol. 2012;52(3):396-399.
- You J, Yaqoob P. Evidence of immunomodulatory effects of a novel probiotic, Bifidobacterium longum bv. infantis CCUG 52486. FEMS Immunol Med Microbiol. 2012;66(3):353-362.
- Huang R, Wang K, Hu J. Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2016;8(8). doi:10.3390/nu8080483
- Whorwell PJ, Altringer L, Morel J, et al. Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome. Am J Gastroenterol. 2006;101(7):1581-1590.
- Bernini LJ, Simão ANC, Alfieri DF, et al. Beneficial effects of Bifidobacterium lactis on lipid profile and cytokines in patients with metabolic syndrome: A randomized trial. Effects of probiotics on metabolic syndrome. Nutrition. 2016;32(6):716-719.
- Waitzberg DL, Quilici FA, Michzputen S, Friche Passos M do C. THE EFFECT OF PROBIOTIC FERMENTED MILK THAT INCLUDES BIFIDOBACTERIUM LACTIS CNCM I-2494 ON THE REDUCTION OF GASTROINTESTINAL DISCOMFORT AND SYMPTOMS IN ADULTS: A NARRATIVE REVIEW. Nutr Hosp. 2015;32(2):501-509.
- Matsumoto M, Benno Y. Anti-inflammatory metabolite production in the gut from the consumption of probiotic yogurt containing Bifidobacterium animalis subsp. lactis LKM512. Biosci Biotechnol Biochem. 2006;70(6):1287-1292.
- Akatsu H, Iwabuchi N, Xiao J-Z, et al. Clinical effects of probiotic Bifidobacterium longum BB536 on immune function and intestinal microbiota in elderly patients receiving enteral tube feeding. JPEN J Parenter Enteral Nutr. 2013;37(5):631-640.
- Xiao JZ, Kondo S, Takahashi N, et al. Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers. J Dairy Sci. 2003;86(7):2452-2461.
- Namba K, Hatano M, Yaeshima T, Takase M, Suzuki K. Effects of Bifidobacterium longum BB536 administration on influenza infection, influenza vaccine antibody titer, and cell-mediated immunity in the elderly. Biosci Biotechnol Biochem. 2010;74(5):939-945.
- Liu Y-P, Liu X, Dong L. [Lactulose plus live binary Bacillus subtilis in the treatment of elders with functional constipation]. Zhonghua Yi Xue Za Zhi. 2012;92(42):2961-2964.
- Akbari E, Asemi Z, Daneshvar Kakhaki R, et al. Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer’s Disease: A Randomized, Double-Blind and Controlled Trial. Front Aging Neurosci. 2016;8:256.
- Kelesidis T, Pothoulakis C. Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders. Therap Adv Gastroenterol. 2012;5(2):111-125.
- Rajabian A, Hosseini A, Hosseini M, Sadeghnia HR. A Review of Potential Efficacy of Saffron (Crocus sativus L.) in Cognitive Dysfunction and Seizures. Prev Nutr Food Sci. 2019;24(4):363-372.
- Agha-Hosseini M, Kashani L, Aleyaseen A, et al. Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo-controlled trial. BJOG. 2008;115(4):515-519.
- Khazdair MR, Boskabady MH, Hosseini M, Rezaee R, M Tsatsakis A. The effects of Crocus sativus (saffron) and its constituents on nervous system: A review. Avicenna J Phytomed. 2015;5(5):376-391.
- Liu F, Prabhakar M, Ju J, Long H, Zhou H-W. Effect of inulin-type fructans on blood lipid profile and glucose level: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2017;71(1):9-20.
- Nicolucci AC, Hume MP, Martínez I, Mayengbam S, Walter J, Reimer RA. Prebiotics Reduce Body Fat and Alter Intestinal Microbiota in Children Who Are Overweight or With Obesity. Gastroenterology. 2017;153(3):711-722.
- Watson AW, Houghton D, Avery PJ, et al. Changes in stool frequency following chicory inulin consumption, and effects on stool consistency, quality of life and composition of gut microbiota. Food Hydrocoll. 2019;96:688-698.