What Makes a Great Probiotic?

What Makes a Great Probiotic?

By Gary Mancuso,
Founder of Doctors Pick

Choosing a probiotic and not sure how to sift through the seeming endless choices? What really makes a great daily probiotic and what should you look for?

Read on and we’ll give you some things to look for as a guide:

1. Diversity of Probiotic Strains: A relatively healthy person has between 300 to 500 different bacteria strains. Probiotics are “useful” bacteria, and the body needs different types (called “strains”) for various functions. So, a great daily probiotic should have a good assortment of those probiotic strains that clinical research shows to be most helpful in humans.

2. Proper Dosage of Each Probiotic Strain: Just because a probiotic formula lists a particular probiotic strain on the label, doesn’t mean it will be much help. It must also contain a meaningful amount, which is that shown in clinical trials on human participants to be effective. This is why the next point—Full Disclosure—is so important on a probiotic label.

3. Full Disclosure of the Amounts of Each Probiotic Strain: There’s a gimmick in the probiotic business that you see on many labels for probiotic formulas: “Proprietary Formula”. This allows the maker of the probiotic to just list the probiotic strains used, but not the actual amounts of each. But the amount of each probiotic strain is key, not just it’s presence.

It’s a dirty secret in the probiotic manufacturing segment about “proprietary formulas”. Often, “proprietary formula” is claimed because the maker of the product is loading up their capsules with the cheapest probiotic strains and only tiny amount of the more expensive ones—which are often the most effective ones. However, as long as even a trace amount of a particular probiotic strain is in the formula, it can be listed on the label.

To ensure you’re actually getting what you think is in the probiotic formula, be sure to look for those who disclose the exact amount of each probiotic strain on their labels.

4. Non-reliance on Soil Based Organisms (SBOs): SBOs are those commercially sold probiotics that are not native to the human digestive system. While there are a tiny handful of SBO strains that have been shown to be potentially helpful to humans, they should be mostly avoided. Your intestinal system evolved over eons to function efficiently using certain types of (probiotic) bacteria. Introducing things “foreign” to this delicately balanced system is questionable, and potentially harmful.

5. Don’t Overdo it: Mega-High Potency Probiotics Aren’t Good Either: In a marketing effort to stand out from the pack, some probiotic makers have created mega-high dosage capsules. By this, we mean those probiotic formulas that contain a 100 Billion+ CFUs. A high, but “safe” potency would be what you find in the plentiful assortment of those that contain 50 or 60 Billion CFUs. Going higher can be counterproductive.

Your intestinal tract will have an assortment of around 300 to 500 different bacteria species and perhaps one to two trillion total bacteria. By introducing a mega-dose on a regular basis, of a relatively few probiotic strains, say 10 or 15, you risk potentially shifting the balance of your various bacteria strains in your gut too much towards these select few. That is not how the intestinal tract was designed to work effectively.

Probiotic supplements are just that—supplementation to your natural system. You want to add small, but effective amounts of certain key probiotics for their demonstrated benefits, not fundamentally alter the mix of the natural bacterial colonies in your gut.

6. Too Many Probiotic Strains in a Formula: Another marketing angle to stand out is putting too many probiotic strains in the formula. Mixing probiotic strains is a delicate art. Some counteract others. Probiotics with 21 or more strains run this risk and may do more harm than good.

 

7. Double Checking for Heavy Metals Toxins: This is important, but not widely practiced in the industry because of added expense. Most makers of probiotics rely on the factory that produces their probiotics to test for toxic heavy metals. But to ensure purity and safety of the product, it is a good idea to also have an independent lab test each production run for heavy metals. To ensure purity of your probiotics, you may want to only buy from probiotic makers who post their independent lab Toxic Heavy Metal test results online.

8. Adding “Extra” Amounts of Probiotics to Ensure 100% Potency at Expiration: Another little secret of the probiotic business is that many “guarantees of potency” are actually only warranting the stated amounts at time of production, not till the product’s expiration date. Some “potency guarantees” actually only guarantee—in their fine print—levels as low as 50% potency at expiration. This is extremely misleading.

A great probiotic maker adds a bit extra of each amount of probiotic strain in their capsules than stated. This helps ensure that the natural erosion of the potency over the product’s shelf-life will still leave the product with 100% of the stated amounts of probiotics on the label at expiration.

9. Don’t Forget the Prebiotic!:

The prebiotic component of many probiotic formulas is often seen as an afterthought. But it is anything but. Prebiotics are insoluble fibers that feed and help set the environment for probiotics to thrive. You can get enough prebiotics from whole plant foods. However, studies show that less than 10% of Americans eat anywhere near the recommended daily amounts of veggies, fruits, whole grains and nuts to give them the necessary prebiotic fibers your gut needs.

This makes the prebiotic part of your probiotic formula essential. Look for high amounts in the formula, above 350 mg or more of prebiotic fibers, preferably from whole food sources of inulin.





At Doctors Pick, we make our probiotics following all of the above principles.


We believe ours are the best of the best. Please try them out:

FEM PRO Women’s Daily Probiotic

60 Billion CFUs Probiotic for Men & Women

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THE 15 TOP CLINICALLY STUDIED PROBIOTIC STRAINS IN DOCTORS PICK BROAD PRO

(References at bottom of page: Most studies cited here were conducted on humans; only a relatively few listed involve lab animals.)
Doctors Pick BROAD PRO brings the best science has to offer

References:

 

Lactobacillus Acidophilus
  1. https://www.cancer.gov/publications/dictionaries/cancer-drug/def/probiotic-acidophilus
  2. https://www.ncbi.nlm.nih.gov/pubmed/8551535
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847857/
  4. https://www.ncbi.nlm.nih.gov/pubmed/23747589
  5. https://www.ncbi.nlm.nih.gov/pubmed/10067658
  6. https://www.journalofdairyscience.org/article/S0022-0302(10)00545-X/fulltext
  7. https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(14)60601-7/fulltext

 

Lactobacillus Bulgaricus
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705123/
  2. https://www.ncbi.nlm.nih.gov/pubmed/21986509
  3. https://www.ncbi.nlm.nih.gov/pubmed/20487575
  4. https://www.ncbi.nlm.nih.gov/pubmed/22923109
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680912/
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475728/
  7. https://www.ncbi.nlm.nih.gov/pubmed/8432622
  8. https://www.ncbi.nlm.nih.gov/pubmed/10660098
  9. https://www.ncbi.nlm.nih.gov/pubmed/597607
  10. https://www.ncbi.nlm.nih.gov/pubmed/3564372

 

Lactobacillus Casei:
  1. https://www.ncbi.nlm.nih.gov/pubmed/26419583
  2. https://www.ncbi.nlm.nih.gov/pubmed/26689231
  3. https://www.ncbi.nlm.nih.gov/pubmed/24673738
  4. https://www.ncbi.nlm.nih.gov/pubmed/20838859
  5. https://www.ncbi.nlm.nih.gov/pubmed/21810608
  6. https://www.ncbi.nlm.nih.gov/pubmed/26672414
  7. https://www.ncbi.nlm.nih.gov/pubmed/22505595
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743185/
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744000/
  10. https://www.ncbi.nlm.nih.gov/pubmed/23992486
  11. https://www.ncbi.nlm.nih.gov/pubmed/21329565
  12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858332/
  13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160870/#B55

 

Lactobacillus Fermentum:
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670518/
  2. https://onlinelibrary.wiley.com/doi/abs/10.1002/jsfa.4214
  3. https://www.ncbi.nlm.nih.gov/pubmed/21218486
  4. https://www.sciencedirect.com/science/article/abs/pii/S0899900707000111?via%3Dihub
  5. https://www.ncbi.nlm.nih.gov/pubmed/27447674
  6. https://www.karger.com/Article/Abstract/328512
  7. https://bjsm.bmj.com/content/44/4/222

 

Lactobacillus Gasseri:

38. https://www.ncbi.nlm.nih.gov/pubmed/20216555

  1. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-lactobacillus-gasseri-sbt2055-in-fermented-milk-on-abdominal-adiposity-in-adults-in-a-randomised-controlled-trial/304E3E2EE11E0D3D4F5D85E7046118A1
  2. Kadooka Y et al. Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomized controlled trial. Br J Nutr. 2013 Nov 14;110(9):1696-703.Epub 2013 Apr 25
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391304/
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611107/
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391304/
  6. Miyoshi M et al. Anti-obesity effect of Lactobacillus gasseri SBT2055 accompanied by inhibition of pro-inflammatory gene expression in the visceral adipose tissue in diet-induced obese mice.Eur J Nutr. 2014;53(2):599-606. doi: 10.1007/s00394-013-0568-9. Epub 2013 Aug 6.
  7. https://link.springer.com/article/10.1007%2Fs00203-015-1101-8
  8. https://www.wageningenacademic.com/doi/10.3920/BM2014.0108

 

Lactobacillus Plantarum:
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594053/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419998/
  3. https://www.researchgate.net/publication/304663353_Immunomodulatory_Effects_of_Lactobacillus_plantarum_Lp62_on_Intestinal_Epithelial_and_Mononuclear_Cells
  4. https://www.ncbi.nlm.nih.gov/pubmed/25598393
  5. https://www.ncbi.nlm.nih.gov/pubmed/26620542
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882673/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936756/

 

Lactobacillus Reuteri:
  1. https://www.nature.com/articles/ejcn2012126
  2. https://www.ncbi.nlm.nih.gov/pubmed/22067612
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917019/
  4. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1348-0421.2009.00154.x
  5. https://www.ncbi.nlm.nih.gov/pubmed/25688886
  6. https://www.nature.com/articles/ejcn2012126
  7. https://www.ncbi.nlm.nih.gov/pubmed/25531996
  8. https://www.ncbi.nlm.nih.gov/pubmed/15629974
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813596/
  10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219330/
  11. https://www.omicsonline.org/open-access/beneficial-bacteria-stimulate-youthful-thyroid-gland-activity-2165-7904.1000220.php?aid=26919
  12. https://www.ncbi.nlm.nih.gov/pubmed/19895848

 

Lactobacillus Rhamnosus:
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155824/
  2. https://www.ncbi.nlm.nih.gov/pubmed/24299712
  1. https://www.ncbi.nlm.nih.gov/pubmed/26365389
  2. https://www.ncbi.nlm.nih.gov/pubmed/21899584
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844131/
  4. https://www.ncbi.nlm.nih.gov/pubmed/22692023
  5. https://www.ncbi.nlm.nih.gov/pubmed/22552453
  6. https://www.ncbi.nlm.nih.gov/pubmed/27596801
  7. https://www.ncbi.nlm.nih.gov/pubmed/23957340
  8. https://www.ncbi.nlm.nih.gov/pubmed/22702506
  9. https://www.ncbi.nlm.nih.gov/pubmed/26142892
  10. https://www.ncbi.nlm.nih.gov/pubmed/23740456

 

Bifidobacterium Breve:
  1. https://www.ncbi.nlm.nih.gov/pubmed/15491374
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1720633/
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048518/
  2. https://www.ncbi.nlm.nih.gov/pubmed/12598719
  3. https://www.ncbi.nlm.nih.gov/pubmed/16819382
  1. https://www.ncbi.nlm.nih.gov/pubmed/27590263
  2. https://www.ncbi.nlm.nih.gov/pubmed/15269618
  3. https://academic.oup.com/ajcn/article/93/1/81/4597712
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084046/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034291/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965514/

 

Bifidobacterium Coagulans:
  1. https://www.ncbi.nlm.nih.gov/pubmed/25079465
  2. https://www.ncbi.nlm.nih.gov/pubmed/24271261
  3. https://www.ncbi.nlm.nih.gov/pubmed/2079358
  4. https://www.ncbi.nlm.nih.gov/pubmed/2086441
  5. https://www.ncbi.nlm.nih.gov/pubmed/23786900
  6. https://www.ncbi.nlm.nih.gov/pubmed/26430929
  7. https://www.ncbi.nlm.nih.gov/pubmed/24706266
  8. https://www.ncbi.nlm.nih.gov/pubmed/25196301
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826289/
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947834/
  2. https://www.ncbi.nlm.nih.gov/pubmed/25219857
  3. https://academic.oup.com/jn/article/145/7/1446/4589930
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784472/
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285933/
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443394/
  7. https://www.tandfonline.com/doi/full/10.1080/09168451.2014.972331
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724383/
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769834/
  10. https://www.ncbi.nlm.nih.gov/pubmed/20140275
  11. https://www.ncbi.nlm.nih.gov/pubmed/19332970
  12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129566/
  13. https://www.ncbi.nlm.nih.gov/pubmed/24867512
  14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460128/

 

Bifidobacterium infantis:
  1. https://www.nature.com/articles/pr2004591
  2. https://academic.oup.com/femspd/article/66/3/353/577227
  3. https://www.ncbi.nlm.nih.gov/pubmed/23192454
  1. https://www.ncbi.nlm.nih.gov/pubmed/20460726
  2. https://www.ncbi.nlm.nih.gov/pubmed/17189085
  3. https://gut.bmj.com/content/61/3/354
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744517/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744517/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774839/
  4. https://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.47306-0#tab2
  5. https://www.ncbi.nlm.nih.gov/pubmed/17893165
  6. https://www.ncbi.nlm.nih.gov/pubmed/19291170
  7. https://academic.oup.com/femspd/article/55/3/324/496928
  8. https://www.ncbi.nlm.nih.gov/pubmed/17259812
  9. https://www.ncbi.nlm.nih.gov/pubmed/16689181
  10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997396/
  11. https://www.ncbi.nlm.nih.gov/pubmed/19367213
  12. https://www.ncbi.nlm.nih.gov/pubmed/16863564
  13. https://www.ncbi.nlm.nih.gov/pubmed/26418574
  14. https://www.ncbi.nlm.nih.gov/pubmed/25794930

 

Bifidobacterium Lactis (Note: was called “Bifidobacterium animalis in older studies”):
  1. https://www.sciencedirect.com/science/article/abs/pii/S089990071500461X?via%3Dihub
  2. https://www.nature.com/articles/pr2008218?proof=true&draft=journal
  3. https://www.ncbi.nlm.nih.gov/pubmed/18801055
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265429/
  5. https://www.ncbi.nlm.nih.gov/pubmed/16794305
  6. https://www.ncbi.nlm.nih.gov/pubmed/19236549
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171707/
  8. https://www.ncbi.nlm.nih.gov/pubmed/26268077
  9. https://www.ncbi.nlm.nih.gov/pubmed/19622191
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877827/
  2. https://www.ncbi.nlm.nih.gov/pubmed/15076628
  3. https://www.ncbi.nlm.nih.gov/pubmed/25599772
  4. https://www.ncbi.nlm.nih.gov/pubmed/15815206
  5. https://www.ncbi.nlm.nih.gov/pubmed/24322191
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761588/
  7. https://www.ncbi.nlm.nih.gov/pubmed/22284965
  8. https://www.ncbi.nlm.nih.gov/pubmed/17635382
  9. https://www.ncbi.nlm.nih.gov/pubmed/18801055

 

Bifidobacterium Longum:

151.https://www.ncbi.nlm.nih.gov/pubmed/15347767

  1. https://www.ncbi.nlm.nih.gov/pubmed/23192454
  2. https://academic.oup.com/femspd/article/66/3/353/577227
  3. https://www.ncbi.nlm.nih.gov/pubmed/22052061
  4. https://www.ncbi.nlm.nih.gov/pubmed/20460726
  5. https://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.47306-0
  6. https://www.ncbi.nlm.nih.gov/pubmed/19291170
  7. https://www.ncbi.nlm.nih.gov/pubmed/17259812
  8. https://www.ncbi.nlm.nih.gov/pubmed/24774670
  9. https://www.ncbi.nlm.nih.gov/pubmed/12906063
  10. https://www.ncbi.nlm.nih.gov/pubmed/16863564
  11. https://www.ncbi.nlm.nih.gov/pubmed/19367213

 

Saccharomyces Boulardii:
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296087/
  2. https://www.ncbi.nlm.nih.gov/pubmed/25653151
  3. https://www.ncbi.nlm.nih.gov/pubmed/15858959
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125647/
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829915/
  6. https://www.ncbi.nlm.nih.gov/pubmed/21997865
  7. https://www.ncbi.nlm.nih.gov/pubmed/18256417
  8. https://www.ncbi.nlm.nih.gov/pubmed/17306006
  9. https://www.ncbi.nlm.nih.gov/pubmed/27283364
  10. https://www.ncbi.nlm.nih.gov/pubmed/22476321
  11. https://www.ncbi.nlm.nih.gov/pubmed/22335323
  12. https://www.ncbi.nlm.nih.gov/pubmed/26216624
  13. https://www.ncbi.nlm.nih.gov/pubmed/7872284
  14. https://www.ncbi.nlm.nih.gov/pubmed/24311316
  15. https://www.ncbi.nlm.nih.gov/pubmed/15740542
  1. https://www.ncbi.nlm.nih.gov/pubmed/16572062
  2. https://www.ncbi.nlm.nih.gov/pubmed/15357564
  3. https://www.ncbi.nlm.nih.gov/pubmed/2494098
  4. https://www.ncbi.nlm.nih.gov/pubmed/7872284
  1. https://www.ncbi.nlm.nih.gov/pubmed/7872284

 

Streptococcus Thermophilus:
  1. https://www.ncbi.nlm.nih.gov/pubmed/14627358
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034325/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526857/

 

Clinical Trial References for FEM PRO Formulation

At Doctors Pick, we only formulate nutritional products based on solid clinical evidence of potential benefits to you. Below is a list of the clinical trials, almost all on human participants, used as the basis for formulating FEM PRO.

References

Lactobacillus Acidophilus
1. https://www.cancer.gov/publications/dictionaries/cancer-drug/def/probiotic-acidophilus
2. https://www.ncbi.nlm.nih.gov/pubmed/8551535
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847857/
4. https://www.ncbi.nlm.nih.gov/pubmed/23747589
5. https://www.ncbi.nlm.nih.gov/pubmed/10067658
6. https://www.journalofdairyscience.org/article/S0022-0302(10)00545-X/fulltext
7. https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(14)60601-7/fulltext

Lactobacillus Bulgaricus
8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705123/
9. https://www.ncbi.nlm.nih.gov/pubmed/21986509
10. https://www.ncbi.nlm.nih.gov/pubmed/20487575
11. https://www.ncbi.nlm.nih.gov/pubmed/22923109
12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680912/
13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475728/
14. https://www.ncbi.nlm.nih.gov/pubmed/8432622
15. https://www.ncbi.nlm.nih.gov/pubmed/10660098
16. https://www.ncbi.nlm.nih.gov/pubmed/597607
17. https://www.ncbi.nlm.nih.gov/pubmed/3564372

Lactobacillus Casei:
18. https://www.ncbi.nlm.nih.gov/pubmed/26419583
19. https://www.ncbi.nlm.nih.gov/pubmed/26689231
20. https://www.ncbi.nlm.nih.gov/pubmed/24673738
21. https://www.ncbi.nlm.nih.gov/pubmed/20838859
22. https://www.ncbi.nlm.nih.gov/pubmed/21810608
23. https://www.ncbi.nlm.nih.gov/pubmed/26672414
24. https://www.ncbi.nlm.nih.gov/pubmed/22505595
25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743185/
26. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744000/
26. https://www.ncbi.nlm.nih.gov/pubmed/23992486
28. https://www.ncbi.nlm.nih.gov/pubmed/21329565
29. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858332/
30. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160870/#B55

Lactobacillus Fermentum:
31. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670518/
32. https://onlinelibrary.wiley.com/doi/abs/10.1002/jsfa.4214
33. https://www.ncbi.nlm.nih.gov/pubmed/21218486
34. https://www.sciencedirect.com/science/article/abs/pii/S0899900707000111?via%3Dihub
35. https://www.ncbi.nlm.nih.gov/pubmed/27447674
36. https://www.karger.com/Article/Abstract/328512
37. https://bjsm.bmj.com/content/44/4/222

Lactobacillus Gasseri:
38. https://www.ncbi.nlm.nih.gov/pubmed/20216555
39. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-lactobacillus-gasseri-sbt2055-in-fermented-milk-on-abdominal-adiposity-in-adults-in-a-randomised-controlled-trial/304E3E2EE11E0D3D4F5D85E7046118A1
40. Kadooka Y et al. Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomized controlled trial. Br J Nutr. 2013 Nov 14;110(9):1696-703.Epub 2013 Apr 25
41. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391304/
42. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611107/
43. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391304/
44. Miyoshi M et al. Anti-obesity effect of Lactobacillus gasseri SBT2055 accompanied by inhibition of pro-inflammatory gene expression in the visceral adipose tissue in diet-induced obese mice.Eur J Nutr. 2014;53(2):599-606. doi: 10.1007/s00394-013-0568-9. Epub 2013 Aug 6.
45. https://link.springer.com/article/10.1007%2Fs00203-015-1101-8
46. https://www.wageningenacademic.com/doi/10.3920/BM2014.0108

Lactobacillus Helveticus:
47. https://www.ncbi.nlm.nih.gov/pubmed/20974015
48. https://www.researchgate.net/publication/282244005_Administration_of_Lactobacillus_helveticus_NS8_improves_behavioral_cognitive_and_biochemical_aberrations_caused_by_chronic_restraint_stress

Lactobacillus Plantarum:
49. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594053/
50. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419998/
51. https://www.researchgate.net/publication/304663353_Immunomodulatory_Effects_of_Lactobacillus_plantarum_Lp62_on_Intestinal_Epithelial_and_Mononuclear_Cells
52. https://www.ncbi.nlm.nih.gov/pubmed/25598393
53. https://www.ncbi.nlm.nih.gov/pubmed/26620542
54. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882673/
55. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936756/

Lactobacillus Reuteri:
56. https://www.nature.com/articles/ejcn2012126
57. https://www.ncbi.nlm.nih.gov/pubmed/22067612
58. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917019/
59. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1348-0421.2009.00154.x
60. https://www.ncbi.nlm.nih.gov/pubmed/25688886
61. https://www.nature.com/articles/ejcn2012126
62. https://www.ncbi.nlm.nih.gov/pubmed/25531996
63. https://www.ncbi.nlm.nih.gov/pubmed/15629974
64. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813596/
65. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219330/
66. https://www.omicsonline.org/open-access/beneficial-bacteria-stimulate-youthful-thyroid-gland-activity-2165-7904.1000220.php?aid=26919
67. https://www.ncbi.nlm.nih.gov/pubmed/19895848

Lactobacillus Rhamnosus:
68. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155824/
69. https://www.ncbi.nlm.nih.gov/pubmed/24299712
70. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239510/
71. https://www.ncbi.nlm.nih.gov/pubmed/26365389
72. https://www.ncbi.nlm.nih.gov/pubmed/21899584
73. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844131/
74. https://www.ncbi.nlm.nih.gov/pubmed/22692023
75. https://www.ncbi.nlm.nih.gov/pubmed/22552453
76. https://www.ncbi.nlm.nih.gov/pubmed/27596801
77. https://www.ncbi.nlm.nih.gov/pubmed/23957340
78. https://www.ncbi.nlm.nih.gov/pubmed/22702506
79. https://www.ncbi.nlm.nih.gov/pubmed/26142892
80. https://www.ncbi.nlm.nih.gov/pubmed/23740456

Bifidobacterium bifidum:
81. https://www.ncbi.nlm.nih.gov/pubmed/27219886
82. https://www.ncbi.nlm.nih.gov/pubmed/27681077
83. https://www.ncbi.nlm.nih.gov/pubmed/28786012
84. https://www.ncbi.nlm.nih.gov/pubmed/28326881
85. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305430/
86. https://www.ncbi.nlm.nih.gov/pubmed/27209439
87. https://www.ncbi.nlm.nih.gov/pubmed/25604727
88. https://www.ncbi.nlm.nih.gov/pubmed/17878180
89. https://www.ncbi.nlm.nih.gov/pubmed/25909149
90. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133134/
91. https://www.ncbi.nlm.nih.gov/pubmed/22205338
92. https://www.ncbi.nlm.nih.gov/pubmed/25648808
93. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570661/
94. https://www.ncbi.nlm.nih.gov/pubmed/25244414
95. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630703/
96. https://www.ncbi.nlm.nih.gov/pubmed/15829425
97. https://www.ncbi.nlm.nih.gov/pubmed/27623957
98. https://www.ncbi.nlm.nih.gov/pubmed/1597660
99. https://www.ncbi.nlm.nih.gov/pubmed/21418261
100. https://www.ncbi.nlm.nih.gov/pubmed/18785988
101. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874795/

Bifidobacterium Breve:
102. https://www.ncbi.nlm.nih.gov/pubmed/15491374
103. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1720633/
104. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048518/
105. https://www.ncbi.nlm.nih.gov/pubmed/12598719
106. https://www.ncbi.nlm.nih.gov/pubmed/16819382
107. https://www.ncbi.nlm.nih.gov/pubmed/27590263
108. https://www.ncbi.nlm.nih.gov/pubmed/15269618
109. https://academic.oup.com/ajcn/article/93/1/81/4597712
110. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084046/
111. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034291/
112. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965514/

Bifidobacterium Coagulans:
113. https://www.ncbi.nlm.nih.gov/pubmed/25079465
114. https://www.ncbi.nlm.nih.gov/pubmed/24271261
115. https://www.ncbi.nlm.nih.gov/pubmed/2079358
116. https://www.ncbi.nlm.nih.gov/pubmed/2086441
117. https://www.ncbi.nlm.nih.gov/pubmed/23786900
118. https://www.ncbi.nlm.nih.gov/pubmed/26430929
119. https://www.ncbi.nlm.nih.gov/pubmed/24706266
120. https://www.ncbi.nlm.nih.gov/pubmed/25196301
121. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826289/
122. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947834/
123. https://www.ncbi.nlm.nih.gov/pubmed/25219857
124. https://academic.oup.com/jn/article/145/7/1446/4589930
125. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784472/
126. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285933/
127. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443394/
128. https://www.tandfonline.com/doi/full/10.1080/09168451.2014.972331
129. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724383/
130. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769834/
131. https://www.ncbi.nlm.nih.gov/pubmed/20140275
132. https://www.ncbi.nlm.nih.gov/pubmed/19332970
133. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129566/
134. https://www.ncbi.nlm.nih.gov/pubmed/24867512
135. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460128/

Bifidobacterium infantis:
136. https://www.nature.com/articles/pr2004591
137. https://academic.oup.com/femspd/article/66/3/353/577227
138. https://www.ncbi.nlm.nih.gov/pubmed/23192454
139. https://www.ncbi.nlm.nih.gov/pubmed/20460726
140. https://www.ncbi.nlm.nih.gov/pubmed/17189085
141. https://gut.bmj.com/content/61/3/354
142. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744517/
143. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744517/
144. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774839/
145. https://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.47306-0#tab2
146. https://www.ncbi.nlm.nih.gov/pubmed/17893165
147. https://www.ncbi.nlm.nih.gov/pubmed/19291170
148. https://academic.oup.com/femspd/article/55/3/324/496928
149. https://www.ncbi.nlm.nih.gov/pubmed/17259812
150. https://www.ncbi.nlm.nih.gov/pubmed/16689181
151. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997396/
152. https://www.ncbi.nlm.nih.gov/pubmed/19367213
153. https://www.ncbi.nlm.nih.gov/pubmed/16863564
154. https://www.ncbi.nlm.nih.gov/pubmed/26418574
155. https://www.ncbi.nlm.nih.gov/pubmed/25794930

Bifidobacterium Lactis (Note: was called “Bifidobacterium animalis in older studies”):
156. https://www.sciencedirect.com/science/article/abs/pii/S089990071500461X?via%3Dihub
157. https://www.nature.com/articles/pr2008218?proof=true&draft=journal
158. https://www.ncbi.nlm.nih.gov/pubmed/18801055
159. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265429/
160. https://www.ncbi.nlm.nih.gov/pubmed/16794305
161. https://www.ncbi.nlm.nih.gov/pubmed/19236549
162. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171707/
163. https://www.ncbi.nlm.nih.gov/pubmed/26268077
164. https://www.ncbi.nlm.nih.gov/pubmed/19622191
165. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877827/
166. https://www.ncbi.nlm.nih.gov/pubmed/15076628
167. https://www.ncbi.nlm.nih.gov/pubmed/25599772
168. https://www.ncbi.nlm.nih.gov/pubmed/15815206
169. https://www.ncbi.nlm.nih.gov/pubmed/24322191
170. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761588/
171. https://www.ncbi.nlm.nih.gov/pubmed/22284965
172. https://www.ncbi.nlm.nih.gov/pubmed/17635382
173. https://www.ncbi.nlm.nih.gov/pubmed/18801055

Bifidobacterium Longum:
174. https://www.ncbi.nlm.nih.gov/pubmed/15347767
175. https://www.ncbi.nlm.nih.gov/pubmed/23192454
176. https://academic.oup.com/femspd/article/66/3/353/577227
177. https://www.ncbi.nlm.nih.gov/pubmed/22052061
178. https://www.ncbi.nlm.nih.gov/pubmed/20460726
178. https://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.47306-0
180. https://www.ncbi.nlm.nih.gov/pubmed/19291170
181. https://www.ncbi.nlm.nih.gov/pubmed/17259812
182. https://www.ncbi.nlm.nih.gov/pubmed/24774670
183. https://www.ncbi.nlm.nih.gov/pubmed/12906063
184. https://www.ncbi.nlm.nih.gov/pubmed/16863564
185. https://www.ncbi.nlm.nih.gov/pubmed/19367213

Bacillus Subtilis:
186. https://www.ncbi.nlm.nih.gov/pubmed/23328284
187. https://www.microbiologyresearch.org/content/journal/jmmcr/10.1099/jmmcr.0.004036
188. DOI: https://doi.org/10.1016/j.celrep.2019.12.078

Saccharomyces Boulardii:
189. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296087/
190. https://www.ncbi.nlm.nih.gov/pubmed/25653151
191. https://www.ncbi.nlm.nih.gov/pubmed/15858959
192. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125647/
193. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829915/
194. https://www.ncbi.nlm.nih.gov/pubmed/21997865
195. https://www.ncbi.nlm.nih.gov/pubmed/18256417
196. https://www.ncbi.nlm.nih.gov/pubmed/17306006
197. https://www.ncbi.nlm.nih.gov/pubmed/27283364
198. https://www.ncbi.nlm.nih.gov/pubmed/22476321
199. https://www.ncbi.nlm.nih.gov/pubmed/22335323
200. https://www.ncbi.nlm.nih.gov/pubmed/26216624
201. https://www.ncbi.nlm.nih.gov/pubmed/7872284
202. https://www.ncbi.nlm.nih.gov/pubmed/24311316
203. https://www.ncbi.nlm.nih.gov/pubmed/15740542
204. https://www.ncbi.nlm.nih.gov/pubmed/16572062
205. https://www.ncbi.nlm.nih.gov/pubmed/15357564
206. https://www.ncbi.nlm.nih.gov/pubmed/2494098
207. https://www.ncbi.nlm.nih.gov/pubmed/7872284
208. https://www.frontiersin.org/articles/10.3389/fnagi.2016.00256/full

Saffron:
209: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599112/
210: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643654/
211. https://www.ncbi.nlm.nih.gov/pubmed/27595298
212. https://www.ncbi.nlm.nih.gov/pubmed/15707766
213. https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/j.1471-0528.2007.01652.x
214. https://www.ncbi.nlm.nih.gov/pubmed/19720342
215. https://www.ncbi.nlm.nih.gov/pubmed/20831681
216. https://www.ncbi.nlm.nih.gov/pubmed/19838862
217. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941716/
218. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850693/
219. https://www.ncbi.nlm.nih.gov/pubmed/20688744
220. https://www.ncbi.nlm.nih.gov/pubmed/30343354

Inubio™ Prebiotic Ingredients—Inulin, Chicory Root & Jerusalem Artichoke:
221. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686634/
222. https://www.ncbi.nlm.nih.gov/pubmed/28596023?dopt=Abstract
223. ttps://academic.oup.com/jn/search-results?f_TocHeadingTitle=Inulin%20and%20Oligofructose:%20Health%20Benefits%20and%20Claims-A%20Critical%20Review
224. https://academic.oup.com/jn/article/137/11/2524S/4664499
225. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705355/
226. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896694/
227. https://www.ncbi.nlm.nih.gov/pubmed/24688953
228. https://www.ncbi.nlm.nih.gov/pubmed/18853230
229. https://www.ncbi.nlm.nih.gov/pubmed/27623982
230. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041804/